Tomonal

Tomonal™

Redox Homeostasis

Tomonal is a uniquely formulated natural supplement that supports antioxidative signals and restores cellular redox homeostasis. It has anti-inflammatory, anti-tumoral, and pain relief capabilities.

FUNCTIONS

Artemisinin and its derivatives are commonly used in malaria therapy. Recently, a growing amount of research has focused on its anticancer properties. One study that tested 55 cell lines from the Developmental Therapeutics Program of the National Cancer Institute (NCI) showed that Artemisinin displayed inhibitory activity against leukemia, colon, melanoma, breast, ovarian, prostate, central nervous system (CNS), and renal cancer cells [1]. Cancer cells require a lot of iron in order to support their rapid proliferation. It is known that human cancer cells express more iron transporting protein transferrin than normal cells, and have higher rates of iron intake via these receptors. Artemisinin’s unique structure bears endo-peroxide. This could be a trigger for the generation of active oxygen radicals via homolytic cleavage of the weak oxygen peroxide bond accelerated by higher ferrous iron concentration in cancer cells [2, 3]. Several studies have associated Artemisinin toxicity with impaired cytokinesis, enhanced levels of oxidative stress, inhibition of tumor invasion, migration, and metastasis [4]. Importantly, artemisinin is one of the very few supplements that has been widely used as antimalarial medication with no significant side effects.

Caesalpinia sappan (Su Mu) has long been used in Oriental folk medicines to promote blood circulation, anti-inflammatory, antioxidant activities [5]. Sappan wood extract, via endogenous NO and subsequent cGMP formation, promote blood circulation to remove blood stasis, decreases swelling, and promotes micro-circulation. Three different crude fractions from Sappan wood were found to show peripheral analgesic activity [6], which inhibits the voltage-gated sodium channel and have painkilling effects.

Copper Copper is an essential trace mineral. All tissues in the body need it for normal metabolic functions. It is excellent at reducing inflammations, strengthening connective tissue, restoring hair color, regulating oxidative energy metabolism, as well as fighting parasites and cancer.

Zinc has strong anti-inflammatory and antibiotic properties but is often deficient with a high copper intake. Therefore, it is usually best to increase the intake of both minerals together. Both Zn and Cu are co-factors of most important antioxidant enzyme Cu/Zn-SOD, critical to cellular redox homeostasis.

SUGGESTED USE

Adults take 1 capsules. Three times daily after meals or as directed by a healthcare professional.

INGREDIENTS

Artemisia annua, Caesalpinia sappan (Su Mu), Zinc and copper. Artemisia annua, Caesalpinia sappan (Su Mu), Zinc and copper.

SIDE EFFECTS

No adverse side effects reported.

STORAGE

Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCES

1. Efferth, T., et al., Molecular modes of action of artesunate in tumor cell lines. Molecular Pharmacology, 2003. 64(2): p. 382-394.

2. Chaturvedi, D., et al., Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents. Chemical Society Reviews, 2010. 39(2): p. 435-454.

3. Nakase, I., et al., Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation. International journal of pharmaceutics, 2008. 354(1): p. 28-33.

4. Xu, Q., et al., Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo. Journal of Zhejiang University SCIENCE B, 2011. 12(4): p. 247-255.

5. Pawar, C.R., A.D. Landge, and S.J. Surana, Phytochemical and pharmacological aspects of Caesalpinia sappan. Journal of Pharmacy Research Vol, 2008. 1(2).

6. Hemalatha, K., et al., Analgesic Activity of Caesalpinia sappan. Heartwood. Pharmaceutical Biology, 2007. 45(5): p. 360-362.Tomonal